Anti-ulcerogenic lignans from Taxus baccata L.

نویسندگان

  • Ilhan Gurbuz
  • Nurgun Erdemoglu
  • Erdem Yesilada
  • Bilge Sener
چکیده

Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-iso-lariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.

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عنوان ژورنال:
  • Zeitschrift fur Naturforschung. C, Journal of biosciences

دوره 59 3-4  شماره 

صفحات  -

تاریخ انتشار 2004